Epoplus is a form of erythropoietin (EPO) manufactured by using the recombinant DNA technology. EPO is essentially produced by the kidneys in the body and stimulates the bone marrow. This in turn causes an increase in the production of blood cells. Insufficient blood cell production leads to severe cases of anemia. In other words, renal failure or severe kidney diseases are generally associated with anemia. Epoplus is an antianemic prescribed for severe cases of anemia associated with chronic renal failure as well as pre-dialysis patients.